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There might be better ways to accomplish what I'm after, if so please let me know. There's a big audience of podcasters and online radio show hosts out there that are severely underserved by current audio apps.I want to interview someone via Skype whilst livestreaming to Spreaker. I want them to hear the cleaned version of my mic feed, not the grim sibilant and humming version. On first audio tab I set input as my mic, then filter it to remove sibilance and hum, then output to Soundflower (SF) 64ch on channels 1 & 3. On Skype I set input device as SF 64ch.Now I want the guest's voice to also be cleaned - removing hum, high-pitch feedback loops, etc. I set output of Skype to SF 2ch. In Audio Plugin Player, on 2nd Audio Input tab, I use SF 2ch as the input, filter it and output to channels 2 & 4 of SF 64ch.Now, SF 64ch has 4 channels of clean audio:1 & 3 = My voice (left & right)2 & 4 = Guest voice (left & right)I stream SF 64ch to Spreaker, but spreaker only listens to channels 1 & 2 = My voice (left channel) & Guest voice (right channel).Guest hears cleaned version of my voice, I hear clear version of their voice, Spreaker listeners hear both. I can mute my voice in my headphones via soundflower by setting 64ch channels 1 & 3 to "None" output device.Using Line In app, I can take output of DJ app or other sound source and route to some other channel so I hear customer in one ear, music queueing in the other. That sort of thing.